Evaluation of PCL Electrospun Scaffolds Concentration on Metformin Hydrochloride Release Ratio

The study investigates the effect of polycaprolactone (PCL) concentration on metformin hydrochloride (MH) release ratio electrospun nanofiber scaffolds. Blend and emulsion electrospinning are used to produce performance nanofibrous scaffolds was evaluated by morphology (Field Emission Scanning Electron Microscopy, FESEM), chemical (Fourier Transform Infrared Spectroscopy, FTIR), thermal (Differential Calorimetry, DSC), wettability, porosity, mechanical tests, in vitro drug release. average fiber diameter ranged from (189.29-2893.93 nm) according FESEM results, it increased with PCL concentration. scaffold, prepared blend method (259.64±6.1 nm), is lower than that scaffold produced (487.45±22.53 nm). Melting points all drug-loaded were identical those pure polymer. Compared nanofibers, nanofibers showed a marked increase hydrophilicity. tensile strength indicated an improvement properties decrease diameter. Moreover, results show Metformin decreases polycaprolactone. Total MH (5% w/v) PCL-MH fibrous for three-week 71.11 % 93.91 methods, respectively. because encapsulated polymer surfactant, which improves control long-term delivery system DDS.